Amniotic membrane transplantation as part of a multimodal management approach to Streptococcus pyogenes necrotizing keratoconjunctivitis

J AAPOS. 2024 Jun;28(3):103900. doi: 10.1016/j.jaapos.2024.103900. Epub 2024 Mar 25.

Abstract

Streptococcus pyogenes (group A beta-hemolytic Streptococcus, GABHS) causes a range of human infections, including necrotizing fasciitis and toxic shock syndrome, because it produces exotoxins that damage host cells, facilitate immune evasion, and serve as T cell superantigens. GABHS conjunctivitis is rare. We report a case of membranous conjunctivitis in a 3-year-old child who was treated with a combination of targeted bactericidal antimicrobials, toxin-synthesis inhibition, and amniotic membrane transplantation.

Publication types

  • Case Reports

MeSH terms

  • Amnion* / transplantation
  • Anti-Bacterial Agents* / therapeutic use
  • Child, Preschool
  • Combined Modality Therapy
  • Conjunctivitis, Bacterial / diagnosis
  • Conjunctivitis, Bacterial / drug therapy
  • Conjunctivitis, Bacterial / microbiology
  • Drug Therapy, Combination
  • Eye Infections, Bacterial / diagnosis
  • Eye Infections, Bacterial / drug therapy
  • Eye Infections, Bacterial / microbiology
  • Female
  • Humans
  • Keratoconjunctivitis* / diagnosis
  • Keratoconjunctivitis* / drug therapy
  • Keratoconjunctivitis* / microbiology
  • Keratoconjunctivitis* / surgery
  • Male
  • Streptococcal Infections* / diagnosis
  • Streptococcal Infections* / drug therapy
  • Streptococcal Infections* / microbiology
  • Streptococcus pyogenes* / isolation & purification

Substances

  • Anti-Bacterial Agents