A phase 1 dose-escalation study of low-dose lenalidomide maintenance post-allogeneic stem cell transplantation for high-risk acute myeloid leukaemia or myelodysplastic syndrome

Ray Mun Koo; Eric Wong; Joanne E Davis; Travis Perera; Andrew Lim; Rachel M Koldej; David S Ritchie

doi:10.1038/s41409-023-02195-x

A phase 1 dose-escalation study of low-dose lenalidomide maintenance post-allogeneic stem cell transplantation for high-risk acute myeloid leukaemia or myelodysplastic syndrome

Bone Marrow Transplant. 2024 Jul;59(7):1025-1027. doi: 10.1038/s41409-023-02195-x. Epub 2024 Mar 27.

Authors

Ray Mun Koo^{1

2

3}, Eric Wong^{1

2

4}, Joanne E Davis^{1

2}, Travis Perera^{1

3

5}, Andrew Lim^{1

2

4}, Rachel M Koldej^{1

2}, David S Ritchie^{6

7

8}

Affiliations

¹ ACRF Translational Research Laboratory, Royal Melbourne Hospital, Melbourne, VIC, Australia.
² Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.
³ Clinical Haematology, Peter MacCallum Cancer Centre-Royal Melbourne Hospital, Melbourne, VIC, Australia.
⁴ Department of Clinical Haematology, Austin Health, Melbourne, VIC, Australia.
⁵ Wellington Blood and Cancer Centre, Wellington Hospital, Wellington, New Zealand.
⁶ ACRF Translational Research Laboratory, Royal Melbourne Hospital, Melbourne, VIC, Australia. [email protected].
⁷ Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia. [email protected].
⁸ Clinical Haematology, Peter MacCallum Cancer Centre-Royal Melbourne Hospital, Melbourne, VIC, Australia. [email protected].

PMID: 38538726
DOI: 10.1038/s41409-023-02195-x

No abstract available

Publication types

Clinical Trial, Phase I
Letter

MeSH terms

Adult
Aged
Allografts
Female
Hematopoietic Stem Cell Transplantation* / methods
Humans
Lenalidomide* / administration & dosage
Lenalidomide* / therapeutic use
Leukemia, Myeloid, Acute* / therapy
Male
Middle Aged
Myelodysplastic Syndromes* / therapy
Transplantation, Homologous / methods

Substances

Lenalidomide