Treatment With Voclosporin and Anifrolumab in a Patient With Lupus Nephritis and Refractory Discoid Lupus Erythematosus: A Case Report and Literature Review

Ralina Karagenova; Ziga Vodusek; Rebecca Krimins; Adam Krieger; Homa Timlin

doi:10.7759/cureus.55321

Treatment With Voclosporin and Anifrolumab in a Patient With Lupus Nephritis and Refractory Discoid Lupus Erythematosus: A Case Report and Literature Review

Cureus. 2024 Mar 1;16(3):e55321. doi: 10.7759/cureus.55321. eCollection 2024 Mar.

Authors

Ralina Karagenova¹, Ziga Vodusek², Rebecca Krimins³, Adam Krieger², Homa Timlin²

Affiliations

¹ Rheumatology, University of Hawaii John A. Burns School of Medicine, Honolulu, USA.
² Rheumatology, Johns Hopkins University School of Medicine, Baltimore, USA.
³ Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, USA.

Abstract

Systemic lupus erythematosus (SLE) is a complex heterogeneous disease with multiple clinical manifestations. Recently, two medications, anifrolumab and voclosporin, have been approved for the treatment of adults with SLE and lupus nephritis (LN), respectively. We present the case of an elderly woman with LN and refractory discoid lupus erythematosus (DLE), who was treated successfully with a combination of voclosporin and anifrolumab without major infections.

Keywords: anifrolumab; discoid lupus erythematosus (dle); lupus nephritis; sle; sle and lupus nephritis; systemic lupus erythematosus; voclosporin.

Publication types

Case Reports