Poor performance of paired tests of latent tuberculosis in highly immune-compromised individuals exposed to multidrug-resistant tuberculosis: time for new diagnostic markers

Geoffrey Eather; Malcolm Wilson; Celine Goffinet; Elizabeth Ryan

doi:10.1183/23120541.00732-2023

Poor performance of paired tests of latent tuberculosis in highly immune-compromised individuals exposed to multidrug-resistant tuberculosis: time for new diagnostic markers

ERJ Open Res. 2024 Apr 8;10(2):00732-2023. doi: 10.1183/23120541.00732-2023. eCollection 2024 Mar.

Authors

Geoffrey Eather^{1

2

3}, Malcolm Wilson¹, Celine Goffinet¹, Elizabeth Ryan⁴

Affiliations

¹ Metro South Clinical Tuberculosis Service, Woolloongabba, Australia.
² Department of Respiratory Medicine, Princess Alexandra Hospital, Woolloongabba, Australia.
³ University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, Australia.
⁴ Queensland Cyber Infrastructure Foundation, University of Queensland, St Lucia, Australia.

Abstract

Guideline-based recommendations for diagnosis of latent TB in highly immune suppressed populations are difficult to interpret and poorly characterised. More accurate biomarkers independent of T-cell functions are urgently required. https://bit.ly/41P8vTa.