Tofacitinib as a Rescue Therapy for Ulcerative Colitis in Pregnancy

Inflamm Bowel Dis. 2024 May 2;30(5):868-870. doi: 10.1093/ibd/izae076.
No abstract available

Keywords: pregnancy; tofacitinib; ulcerative colitis.

Plain language summary

Tofacitinib, a potentially teratogenic nonselective Janus Kinase inhibitor was used as salvage therapy for ulcerative colitis during pregnancy with corticosteroids, maintenance ustekinumab, and rectal 5-ASA therapy. Corticosteroid-free remission ensued, resulting in term delivery without congenital malformations and avoidance of colectomy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Colitis, Ulcerative* / drug therapy
  • Female
  • Humans
  • Janus Kinase Inhibitors / therapeutic use
  • Piperidines* / therapeutic use
  • Pregnancy
  • Pregnancy Complications* / drug therapy
  • Pyrimidines* / therapeutic use

Substances

  • Piperidines
  • Pyrimidines
  • tofacitinib
  • Janus Kinase Inhibitors