Abstract
The non-canonical amino acid adamantylglycine (Ada) is introduced into peptides to allow high-affinity binding to cucurbit[7]uril (CB7). Introduction of Ada into a cell-penetrating peptide (CPP) sequence had minimal influence on the membrane transport, yet enabled up- and down-regulation of the membrane transport activity.
MeSH terms
-
Adamantane / analogs & derivatives
-
Adamantane / chemistry
-
Biological Transport
-
Bridged-Ring Compounds / chemistry
-
Bridged-Ring Compounds / metabolism
-
Cell Membrane / chemistry
-
Cell Membrane / metabolism
-
Cell-Penetrating Peptides* / chemistry
-
Cell-Penetrating Peptides* / metabolism
-
Glycine* / analogs & derivatives
-
Glycine* / chemistry
-
Glycine* / metabolism
-
Heterocyclic Compounds, 2-Ring*
-
Humans
-
Imidazoles / chemistry
-
Imidazolidines*
-
Macrocyclic Compounds*
Substances
-
Glycine
-
Cell-Penetrating Peptides
-
Imidazoles
-
Bridged-Ring Compounds
-
cucurbit(7)uril
-
Adamantane
-
Heterocyclic Compounds, 2-Ring
-
Macrocyclic Compounds
-
Imidazolidines