Bariatric Surgery and Its Metabolic Echo Effect on Serum Uric Acid Levels

Subodh Bashyal; Shen Qu; Manoj Karki

doi:10.7759/cureus.58103

Bariatric Surgery and Its Metabolic Echo Effect on Serum Uric Acid Levels

Cureus. 2024 Apr 12;16(4):e58103. doi: 10.7759/cureus.58103. eCollection 2024 Apr.

Authors

Subodh Bashyal¹, Shen Qu^{1

2

3}, Manoj Karki⁴

Affiliations

¹ Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, CHN.
² Shanghai Center of Thyroid Diseases, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, CHN.
³ SinoUnited Health, Endocrinology, Metabolism and Thyroid Center, Shanghai, CHN.
⁴ Department of Internal Medicine, Endocrinology and Metabolism, Universal College of Medical Sciences, Tribhuvan University, Bhairahawa, NPL.

Abstract

Bariatric surgery (BS) has been a significant means of reducing weight in obese individuals. The metabolic changes after bariatric surgery are crucial as they extend its advantages beyond weight loss. As its name implies, "metabolic surgery" also addresses obesity-related metabolic concerns. Bariatric surgery has always been associated with lessened serum uric acid (SUA) levels. In this review, we examined current studies to understand how surgical therapies impact serum uric acid levels. Strongly minded on the extent and timing of changes in the level of serum uric acid after bariatric surgeries. We conducted a comprehensive search for relevant current studies in PubMed, Google Scholar, JAMA, and the Cochrane Library until February 1, 2024. We aimed to analyze the metabolic advantages of bariatric surgery, focusing on its function in treating hyperuricemia and lowering the risk of associated disorders. Our review elaborates on factors contributing to decreased serum uric acid levels after bariatric surgery, such as alterations in renal function, insulin sensitivity, and inflammatory markers.

Keywords: bariatric surgery; gout crystals; hyperuricemia; metabolic syndrome (mets); serum uric acid.

Publication types

Review

Grants and funding

This work was supported by the National Key R&D Program of China (No. 2018YFC1314101, 2016YFC1305600), the National Natural Science Foundation of China (82170861, 81970677), the Fundamental Research Funds for the Central Universities of Tongji University (22120190210), the Clinical Research Plan of SHDC (SHDC2020CR1017B), and the Shanghai Committee of Science and Technology, China (19DZ1910200, 18411951803, 17DZ1910603).