Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance

Tamam Bakchoul; Stefanie Hammer; Peter Lang; Peter Rosenberger

doi:10.1016/j.tru.2020.100008

Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance

Thromb Update. 2020 Dec:1:100008. doi: 10.1016/j.tru.2020.100008. Epub 2020 Aug 26.

Authors

Tamam Bakchoul¹, Stefanie Hammer¹, Peter Lang², Peter Rosenberger³

Affiliations

¹ Transfusion Medicine, University Hospital of Tübingen, Tübingen, Germany.
² Children Hospital, University of Tübingen, Tübingen, Germany.
³ Department of Anaesthesiology and Intensive Care, University of Tübingen, Tübingen, Germany.

Abstract

•To date most reports on COVID-19 associated coagulopathy focused an increased activation of the plasmatic coagulation system.•Using a novel method to assess clot lysis we observed abnormalities in fibrinolysis in COVID-19 infection.•Our finding suggests that fibrinolysis system may contribute to the procoagulatory status in COVID-19 patients.

Keywords: COVID-19; CT, cloting time; Coagulation; EX-Test, extrinsic test; Fibrinolysis; LT, lysis time; M, male; MCF, maximum clot firmness; ML, maximum clot lysis; PLT, platelet count; PT, prothrombin time; SOFA, Sepsis-related organ failure assessment score; TPA, tissue plasminogen activator; aPTT, activated partial thromboplastin time; y, years.