The centrosome: a critical hub for cell cycle regulation

Yuki Yoshino; Zhenzhou Fang; Natsuko Chiba

doi:10.1016/j.tcb.2024.04.003

The centrosome: a critical hub for cell cycle regulation

Trends Cell Biol. 2024 Jun;34(6):437-439. doi: 10.1016/j.tcb.2024.04.003. Epub 2024 Apr 25.

Authors

Yuki Yoshino¹, Zhenzhou Fang², Natsuko Chiba³

Affiliations

¹ Department of Cancer Biology, Institute of Aging, Development, and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Laboratory of Cancer Biology, Graduate School of Life Sciences, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Department of Cancer Biology, Tohoku University Graduate School of Medicine, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan.
² Department of Cancer Biology, Institute of Aging, Development, and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Laboratory of Cancer Biology, Graduate School of Life Sciences, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan.
³ Department of Cancer Biology, Institute of Aging, Development, and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Laboratory of Cancer Biology, Graduate School of Life Sciences, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan; Department of Cancer Biology, Tohoku University Graduate School of Medicine, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan. Electronic address: [email protected].

PMID: 38670849
DOI: 10.1016/j.tcb.2024.04.003

Abstract

Cyclins and cyclin-dependent kinases (CDKs) localize to the centrosome, but their significance in the cell cycle is unclear. Recently, Roberts et al. revealed that centrosomal cyclin B-CDK is required for mitotic entry and phosphorylation of substrates. This suggests that the centrosome acts as a signaling hub controlling the cell cycle.

Keywords: cell cycle; centrosome; cyclin; cyclin-dependent kinase; spindle pole body.

MeSH terms

Animals
Cell Cycle*
Centrosome* / metabolism
Cyclin-Dependent Kinases* / metabolism
Cyclins / metabolism
Humans
Mitosis
Phosphorylation
Signal Transduction

Substances

Cyclin-Dependent Kinases
Cyclins