Managing differential performance of polygenic risk scores across groups: Real-world experience of the eMERGE Network

Affiliations

• ¹ Edmond and Lily Safra Center for Ethics, Harvard University, Cambridge, MA, USA; Department of Genetics, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
• ² Center for Genetic Medicine, Northwestern University, Evanston, IL, USA.
• ³ Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
• ⁴ Invitae, San Francisco, CA, USA.
• ⁵ Center for Genetic Medicine, Northwestern University, Evanston, IL, USA; Department of Pharmacology, Northwestern University, Evanston, IL, USA.
• ⁶ Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Ariadne Labs, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
• ⁷ Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
• ⁸ Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
• ⁹ Division of Medical Genetics, Department of Medicine and Department of Genome Science, University of Washington Medical Center, Seattle, WA, USA.
• ¹⁰ Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Mass General Brigham Personalized Medicine, Boston, MA, USA.
• ¹¹ Institute for Genomic Health, Icahn School of Medicine, New York City, NY, USA; Center for Clinical Translational Genomics, Icahn School of Medicine, New York City, NY, USA; Division of Genomic Medicine, Department of Medicine, Icahn School of Medicine, New York City, NY, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine, New York City, NY, USA.
• ¹² Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
• ¹³ Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• ¹⁴ Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
• ¹⁵ Department of Preventive Medicine, Northwestern University, Evanston, IL, USA.
• ¹⁶ Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; University of Cincinnati College of Medicine, Cincinnati, OH, USA.
• ¹⁷ Mass General Brigham Personalized Medicine, Boston, MA, USA.
• ¹⁸ Center for Genetic Medicine, Northwestern University, Evanston, IL, USA; Department of Preventive Medicine, Northwestern University, Evanston, IL, USA.
• ¹⁹ Center for Precision Medicine and Genomics, Department of Medicine, Columbia University Irving Medical Center, New York City, NY, USA; Division of Ethics, Department of Medical Humanities and Ethics, Columbia University Irving Medical Center, New York City, NY, USA.
• ²⁰ Biomedical Ethics Program, Mayo Clinic, Rochester, MN, USA.
• ²¹ Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Psychiatric & Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
• ²² Division of Genomics and Society, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
• ²³ Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
• ²⁴ Department of Bioethics & Humanities, University of Washington School of Medicine, Seattle, WA, USA.