Pseudohypoaldosteronism and acquired renal aldosterone resistance with hyperkalemic type IV renal tubular acidosis in 2 cats

J Vet Intern Med. 2024 Jul-Aug;38(4):2344-2347. doi: 10.1111/jvim.17098. Epub 2024 May 2.

Abstract

This report describes the diagnosis and treatment of aldosterone resistance (AR) and acquired hyperkalemic type IV renal tubular acidosis (RTA) in 2 cats comparable to acquired pseudohypoaldosteronism in people. One cat developed AR from chronic kidney disease after an acute kidney injury and was treated with furosemide per os, which resolved the hyperkalemic RTA. The second cat developed transient AR secondary to a bacterial urinary tract infection associated with urethral catheterization, and treatment with antibiotics resolved the hyperkalemic RTA.

Keywords: chronic kidney disease; endocrinopathy; hyponatremia; mineralocorticoid.

Publication types

  • Case Reports

MeSH terms

  • Acidosis, Renal Tubular* / complications
  • Acidosis, Renal Tubular* / veterinary
  • Aldosterone* / blood
  • Animals
  • Cat Diseases* / drug therapy
  • Cats
  • Female
  • Furosemide / therapeutic use
  • Hyperkalemia* / veterinary
  • Male
  • Pseudohypoaldosteronism* / veterinary

Substances

  • Aldosterone
  • Furosemide