Malignant melanoma arising in a burn scar

Emily Ma; Shealinna Ge; Walter L Rush; Jill Allbritton

doi:10.1007/s00403-024-02861-0

Malignant melanoma arising in a burn scar

Arch Dermatol Res. 2024 May 2;316(5):146. doi: 10.1007/s00403-024-02861-0.

Authors

Emily Ma¹, Shealinna Ge², Walter L Rush³, Jill Allbritton⁴

Affiliations

¹ University of Maryland School of Medicine, Baltimore Maryland, USA.
² Department of Dermatology, University of Maryland Medical Center, Baltimore, MD, USA.
³ Joint Pathology Center, 606 Stephen Sitter Avenue, Silver Spring, MD, 20910, USA.
⁴ Joint Pathology Center, 606 Stephen Sitter Avenue, Silver Spring, MD, 20910, USA. [email protected].

PMID: 38696005
DOI: 10.1007/s00403-024-02861-0

Abstract

Secondary malignancies are rare but devastating complications of longstanding burn scars. Squamous cell carcinoma is the most common, followed by basal cell carcinoma and melanomas. There are fewer than 50 total reported cases of malignant melanomas arising in burn scars. We report a case of malignant melanoma arising within a longstanding burn scar confirmed by histology, FISH, and PRAME staining to further characterize melanomas arising in burn scars and to illustrate the diagnostic challenges they present.

Keywords: Burn; FISH; Melanoma; PRAME; Scar.

Publication types

Case Reports
Review

MeSH terms

Burns* / complications
Burns* / diagnosis
Burns* / pathology
Cicatrix* / diagnosis
Cicatrix* / etiology
Cicatrix* / pathology
Female
Humans
In Situ Hybridization, Fluorescence
Male
Melanoma* / complications
Melanoma* / diagnosis
Melanoma* / pathology
Melanoma, Cutaneous Malignant
Middle Aged
Skin Neoplasms* / diagnosis
Skin Neoplasms* / etiology
Skin Neoplasms* / pathology
gp100 Melanoma Antigen

Substances

gp100 Melanoma Antigen