Challenges in developing and implementing international best practice guidance for intermediate-risk variants in cancer susceptibility genes: APC c.3920T>A p.(Ile1307Lys) as an exemplar

Affiliations

• ¹ Cancer Genetics Unit, Royal Marsden NHS Foundation Trust, London, UK [email protected] [email protected].
• ² The Institute of Cancer Research, London, UK.
• ³ Clinical Genetics Service, Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
• ⁴ St Vincent's University Hospital, Dublin, Ireland.
• ⁵ St Mark's the National Bowel Hospital and Academic Institute, London, UK.
• ⁶ Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK.
• ⁷ Clinical Genetics, St George's University Hospitals NHS Foundation Trust, London, UK.
• ⁸ Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK.
• ⁹ Imperial College London, London, UK.
• ¹⁰ Faculty of Health and Life Sciences, University of Exeter Medical School, Exeter, UK [email protected] [email protected].
• ¹¹ Peninsula Regional Genetics Service, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.