Estimating Gestational Age and Prediction of Preterm Birth Using Metabolomics Biomarkers

Victoria C Ward; Steven Hawken; Pranesh Chakraborty; Gary L Darmstadt; Kumanan Wilson

doi:10.1016/j.clp.2024.02.012

Estimating Gestational Age and Prediction of Preterm Birth Using Metabolomics Biomarkers

Clin Perinatol. 2024 Jun;51(2):411-424. doi: 10.1016/j.clp.2024.02.012. Epub 2024 Apr 4.

Authors

Victoria C Ward¹, Steven Hawken², Pranesh Chakraborty³, Gary L Darmstadt⁴, Kumanan Wilson⁵

Affiliations

¹ Department of Pediatrics, Stanford University School of Medicine, 291 Campus Drive Li Ka Shing Building, Stanford, CA 94305, USA.
² Clinical Epidemiology Program, Ottawa Hospital Research Institute, Centre for Practice Changing Research, 501 Smyth Road, Box 201-B, Ottawa, Ontario, Canada K1H 8L6; School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Ottawa, Ontario, Canada K1G 5Z3. Electronic address: [email protected].
³ Newborn Screening Ontario, Children's Hospital of Eastern Ontario, 415 Smyth Road, Ottawa, Ontario K1H 8M8, Canada; Department of Pediatrics, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd, Ottawa Ontario, Canada K1H 8M5.
⁴ Prematurity Research Center, Department of Pediatrics, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA 94304, USA.
⁵ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Centre for Practice Changing Research, 501 Smyth Road, Box 201-B, Ottawa, Ontario, Canada K1H 8L6; Department of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5; Bruyère Research Institute, 85 Primrose Avenue, Ottawa, Ontario, Canada K2A2E5.

PMID: 38705649
DOI: 10.1016/j.clp.2024.02.012

Abstract

Preterm birth (PTB) is a leading cause of morbidity and mortality in children aged under 5 years globally, especially in low-resource settings. It remains a challenge in many low-income and middle-income countries to accurately measure the true burden of PTB due to limited availability of accurate measures of gestational age (GA), first trimester ultrasound dating being the gold standard. Metabolomics biomarkers are a promising area of research that could provide tools for both early identification of high-risk pregnancies and for the estimation of GA and preterm status of newborns postnatally.

Keywords: Gestational age; Machine learning; Maternal newborn health; Metabolomics; Newborn screening; Perinatal epidemiology; Prediction modeling; Preterm birth.

Publication types

Review

MeSH terms

Biomarkers* / metabolism
Female
Gestational Age*
Humans
Infant, Newborn
Metabolomics*
Pregnancy
Premature Birth* / metabolism

Substances

Biomarkers