Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities

Young-Hee Kim; Dae-Cheol Choi; Dae-Won Ki; Yeong-Seon Won; Seung-Jae Lee; Ji-Yul Kim; In-Kyoung Lee; Bong-Sik Yun

doi:10.1038/s41429-024-00735-1

Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities

J Antibiot (Tokyo). 2024 Jul;77(7):466-470. doi: 10.1038/s41429-024-00735-1. Epub 2024 May 9.

Authors

Young-Hee Kim¹, Dae-Cheol Choi¹, Dae-Won Ki¹, Yeong-Seon Won^{2

3}, Seung-Jae Lee^{3

4}, Ji-Yul Kim⁵, In-Kyoung Lee⁶, Bong-Sik Yun⁷

Affiliations

¹ Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan, 54596, Republic of Korea.
² Division of Research Management, Department of Bioresource Industrialization, Honam National Institute of Biological Resource, Mokpo, Republic of Korea.
³ Functional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Republic of Korea.
⁴ Department of Applied Biotechnology, University of Science and Technology (UST), Daejeon, 34113, Republic of Korea.
⁵ Department of Genetic Resources Research, National Marine Biodiversity Institute of Korea, Seocheon, Republic of Korea.
⁶ Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan, 54596, Republic of Korea. [email protected].
⁷ Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Gobong-ro 79, Iksan, 54596, Republic of Korea. [email protected].

PMID: 38724631
DOI: 10.1038/s41429-024-00735-1

Abstract

Three new nonenes, verrucanonenes A‒C (1‒3), were isolated from culture broth of marine-derived fungus Albifimbria verrucaria. These compounds were isolated using silica gel column chromatography, reversed-phase medium pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined using a spectroscopic method. Cytotoxicities of these isolated compounds to A549, DU145, HCT116, and HT1080 cancer cell lines were assessed. Compounds 1‒3 exhibited cytotoxicities to DU145 cancer cell line, with IC₅₀ values of 23.4, 28.6, and 20.1 µM, respectively. Compound 2 decreased H1N1-induced cytopathic effects on MDCK cells in a dose-dependent manner.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / isolation & purification
Antineoplastic Agents* / pharmacology
Antiviral Agents* / chemistry
Antiviral Agents* / isolation & purification
Antiviral Agents* / pharmacology
Ascomycota / chemistry
Cell Line, Tumor
Chromatography, High Pressure Liquid
Dogs
Dose-Response Relationship, Drug
Humans
Influenza A Virus, H1N1 Subtype / drug effects
Inhibitory Concentration 50
Madin Darby Canine Kidney Cells
Molecular Structure

Substances

Antiviral Agents
Antineoplastic Agents