In vitro antibacterial activity of sulbactam-durlobactam in combination with other antimicrobial agents against Acinetobacter baumannii-calcoaceticus complex

Sarah M McLeod; Nicole M Carter; Patricia A Bradford; Alita A Miller

doi:10.1016/j.diagmicrobio.2024.116344

In vitro antibacterial activity of sulbactam-durlobactam in combination with other antimicrobial agents against Acinetobacter baumannii-calcoaceticus complex

Diagn Microbiol Infect Dis. 2024 Jul;109(3):116344. doi: 10.1016/j.diagmicrobio.2024.116344. Epub 2024 May 9.

Authors

Sarah M McLeod¹, Nicole M Carter², Patricia A Bradford³, Alita A Miller²

Affiliations

¹ Entasis Therapeutics Inc., an affiliate of Innoviva Specialty Therapeutics, Inc., Waltham, MA, USA. Electronic address: [email protected].
² Entasis Therapeutics Inc., an affiliate of Innoviva Specialty Therapeutics, Inc., Waltham, MA, USA.
³ Antimicrobial Development Specialists, LLC, Nyack, NY, USA.

PMID: 38735147
DOI: 10.1016/j.diagmicrobio.2024.116344

Abstract

Combinations of the β-lactam/β-lactamase inhibitor sulbactam-durlobactam and seventeen antimicrobial agents were tested against strains of Acinetobacter baumannii in checkerboard assays. Most combinations resulted in indifference with no instances of antagonism. These results suggest sulbactam-durlobactam antibacterial activity against A. baumannii is unlikely to be affected if co-dosed with other antimicrobial agents.

Keywords: Acinetobacter baumannii-calcoaceticus complex; Checkerboard; Sulbactam-durlobactam.

MeSH terms

Acinetobacter Infections / drug therapy
Acinetobacter Infections / microbiology
Acinetobacter baumannii* / drug effects
Acinetobacter calcoaceticus / drug effects
Anti-Bacterial Agents* / pharmacology
Azabicyclo Compounds* / pharmacology
Drug Combinations
Humans
Microbial Sensitivity Tests*
Sulbactam* / pharmacology
beta-Lactamase Inhibitors / pharmacology

Substances

Sulbactam
Azabicyclo Compounds
Anti-Bacterial Agents
durlobactam
beta-Lactamase Inhibitors
Drug Combinations