Dequalinium chloride vaginal tablets for recalcitrant Trichomonas vaginalis: A case report

Int J STD AIDS. 2024 Aug;35(9):746-748. doi: 10.1177/09564624241254884. Epub 2024 May 14.

Abstract

Treatment options for recalcitrant Trichomonas vaginalis (TV), when very high dose systemic 5-nitroimidazole plus intravaginal therapy for over 14 days has failed, are very limited. They have poor efficacy, unpleasant side effects, and are difficult and expensive to acquire. We report successful treatment with 24 weeks of daily dequalinium chloride vaginal tablets. Dequalinium is licensed in Europe where it is readily available and cheap. It offers a safe and pragmatic alternative for recalcitrant TV.

Keywords: Trichomonas vaginalis; protozoal disease; treatment.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravaginal
  • Adult
  • Antiprotozoal Agents / administration & dosage
  • Antiprotozoal Agents / therapeutic use
  • Dequalinium*
  • Female
  • Humans
  • Tablets
  • Treatment Outcome
  • Trichomonas Vaginitis* / diagnosis
  • Trichomonas Vaginitis* / drug therapy
  • Trichomonas vaginalis* / drug effects

Substances

  • Dequalinium
  • Tablets
  • Antiprotozoal Agents