PAR caps the poles: a specific role for PARP2-inhibition to target the 'clustering' of extra spindle poles in cancer cells

EBioMedicine. 2024 Jun:104:105158. doi: 10.1016/j.ebiom.2024.105158. Epub 2024 May 14.

Authors

Lin Wang¹, Gerburg M Wulf²

Affiliations

¹ Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.
² Department of Medicine and Cancer Research Institute, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. Electronic address: [email protected].

No abstract available

Publication types

Letter

MeSH terms

Humans
Neoplasms* / drug therapy
Neoplasms* / genetics
Neoplasms* / metabolism
Neoplasms* / pathology
Poly(ADP-ribose) Polymerase Inhibitors* / pharmacology
Poly(ADP-ribose) Polymerase Inhibitors* / therapeutic use
Poly(ADP-ribose) Polymerases* / metabolism
Spindle Apparatus* / metabolism

Substances

Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases
PARP2 protein, human