Topical versus oral corticosteroids in moderate drug reaction with eosinophilia and systemic symptoms: A multicenter randomized clinical trial

Saskia Ingen-Housz-Oro; Elie Guichard; Brigitte Milpied; Benoit Bensaid; Evelyne Collet; Annick Barbaud; Florence Le Duff; Florence Tétart; Angèle Soria; Laurent Machet; Vincent Descamps; Sandrine Monestier; Justine Pasteur; Cécile Morice; Guillaume Chaby; Audrey Colin; Laëtitia Grégoire; Laurence Allanore; Bruno Giraudeau; Olivier Chosidow

doi:10.1016/j.jaad.2024.04.077

Topical versus oral corticosteroids in moderate drug reaction with eosinophilia and systemic symptoms: A multicenter randomized clinical trial

J Am Acad Dermatol. 2024 Sep;91(3):544-547. doi: 10.1016/j.jaad.2024.04.077. Epub 2024 May 14.

Authors

Saskia Ingen-Housz-Oro¹, Elie Guichard², Brigitte Milpied³, Benoit Bensaid⁴, Evelyne Collet⁵, Annick Barbaud⁶, Florence Le Duff⁷, Florence Tétart⁸, Angèle Soria⁶, Laurent Machet⁹, Vincent Descamps¹⁰, Sandrine Monestier¹¹, Justine Pasteur¹², Cécile Morice¹³, Guillaume Chaby¹⁴, Audrey Colin¹⁵, Laëtitia Grégoire¹⁶, Laurence Allanore¹⁷, Bruno Giraudeau¹⁸, Olivier Chosidow¹⁹

Affiliations

¹ Dermatology Department, Henri Mondor Hospital, AP-HP, Créteil, France; French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Refence Center for Toxic Bullous Diseases and Severe Drug Reactions TOXIBUL, Créteil, France; Univ Paris Est Créteil EpiDermE, Créteil, France.
² INSERM CIC1415, CHRU de Tours, Tours, France.
³ French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Dermatology Department, CHU Bordeaux, Bordeaux, France.
⁴ French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Dermatology Department, CHU Edouard Herriot, Lyon, France.
⁵ French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Dermatology Department, CHU Dijon, Dijon, France.
⁶ French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Département de dermatologie et allergologie, Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Tenon, Paris, France.
⁷ Dermatology Department, CHU Nice, Nice, France.
⁸ French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Dermatology Department, CHU Charles Nicolle, Rouen, France.
⁹ Dermatology Department, CHU Tours, Tours, France.
¹⁰ French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Dermatology Department, Bichat Hospital, APHP, Paris, France.
¹¹ Dermatology Department, La Timone Hospital, APHP, Marseille, France.
¹² French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Dermatology Department, Hôpital Estaing, CHU Clermont-Ferrand, Clermont-Ferrand, France.
¹³ French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Dermatology Department, CHU Caen, Caen, France.
¹⁴ Dermatology Department, CHU Amiens, Amiens, France.
¹⁵ Dermatology Department, Henri Mondor Hospital, AP-HP, Créteil, France.
¹⁶ Unité de Recherche Clinique, Henri Mondor Hospital, APHP, Créteil, France.
¹⁷ Dermatology Department, Henri Mondor Hospital, AP-HP, Créteil, France; French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France.
¹⁸ INSERM CIC1415, CHRU de Tours, Tours, France; Université de Tours, Université de Nantes, INSERM, SPHERE U1246, Tours, France.
¹⁹ French Investigators for Skin Adverse Reactions to Drugs (FISARD) Group, Paris, France; Facial Dermatosis Clinic, ENT Department Hôpital Universitaire Pitié-Salpêtrière, AP-HP, Paris, France. Electronic address: [email protected].

PMID: 38754628
DOI: 10.1016/j.jaad.2024.04.077

No abstract available

Keywords: DRESS; adverse drug reaction; noninferiority; randomized controlled trial; systemic corticosteroids; topical corticosteroids; treatment.

Publication types

Multicenter Study
Randomized Controlled Trial
Letter
Comparative Study

MeSH terms

Administration, Oral
Administration, Topical
Adrenal Cortex Hormones / administration & dosage
Adrenal Cortex Hormones / adverse effects
Adult
Aged
Drug Hypersensitivity Syndrome* / diagnosis
Drug Hypersensitivity Syndrome* / etiology
Eosinophilia / chemically induced
Female
Humans
Male
Middle Aged
Severity of Illness Index
Treatment Outcome

Substances

Adrenal Cortex Hormones