Macrophorins H and L, two new HMG-conjugate macrophorins from rihzospheric Penicillium sp. NX-05-G-3

J Asian Nat Prod Res. 2024 Sep;26(9):1041-1048. doi: 10.1080/10286020.2024.2347530. Epub 2024 May 17.

Abstract

Macrophorins H (4) and L (5), two rare HMG-conjugate macrophorins along with three known macrophorins (1-3), three DMOA-derived meroterpenoids (6-8) and two ergosterol derivates (9-10) were isolated from sterilized rice medium cultured Penicillium sp. NX-05-G-3. Their structures were elucidated by 1D and 2D NMR. The cytotoxicities of all compounds were evaluated, and compounds 1 and 2 showed extensive cytotoxicity against human cancer cell lines Hela, SCC15, MDA-MB-453 and A549, with IC50 values ranging from 17.6 to 32.8 µM.

Keywords: Macrophorins; meroterpenoids; rhizosphere fungi, cytotoxicity.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor*
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Penicillium* / chemistry
  • Terpenes / chemistry
  • Terpenes / pharmacology

Substances

  • Antineoplastic Agents
  • Terpenes