The sphinx helps to answer the riddle of cardiac regeneration

Jae Woo Jung; Timothy Hla; Zoltan Arany

doi:10.1016/j.tem.2024.05.003

The sphinx helps to answer the riddle of cardiac regeneration

Trends Endocrinol Metab. 2024 Aug;35(8):677-679. doi: 10.1016/j.tem.2024.05.003. Epub 2024 May 16.

Authors

Jae Woo Jung¹, Timothy Hla², Zoltan Arany³

Affiliations

¹ Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
² Vascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, MA 02115, USA.
³ Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: [email protected].

PMID: 38760201
PMCID: PMC11321922 (available on 2025-08-01)
DOI: 10.1016/j.tem.2024.05.003

Abstract

Cardiomyocyte (CM) death drives heart failure worldwide, and efficient CM regeneration remains a fervently pursued but unachieved goal. Ji and colleagues recently described a novel approach to regeneration by orchestrating divergent sphingolipid signaling pathways in CMs and cardiac fibroblasts (CFs). The findings uncover new biology and offer interesting translational opportunities.

Publication types

Review

MeSH terms

Animals
Fibroblasts / metabolism
Heart / physiology
Heart Failure / metabolism
Humans
Myocytes, Cardiac* / metabolism
Myocytes, Cardiac* / physiology
Regeneration* / physiology
Signal Transduction / physiology
Sphingolipids / metabolism

Substances

Sphingolipids

Abstract

Publication types

MeSH terms

Substances

Grants and funding