Potential Prebiotic Properties of Whey Protein and Glycomacropeptide in Gut Microbiome

Food Sci Anim Resour. 2024 Mar;44(2):299-308. doi: 10.5851/kosfa.2024.e12. Epub 2024 Mar 1.

Abstract

Proteins in whey have prebiotic and antimicrobial properties. Whey protein comprises numerous bioactive proteins and peptides, including glycomacropeptide (GMP), a hydrophilic casein peptide that separates with the whey fraction during cheese making. GMP has traditionally been used as a protein source for individuals with phenylketonuria and also has prebiotic (supporting the growth of Bifidobacterium and lactic acid bacteria) and antimicrobial activities. GMP supplementation may help positively modulate the gut microbiome, help treat dysbiosis-related gastrointestinal disorders and improve overall health in consumers.

Keywords: glycomacropeptide (GMP); gut microbiome; prebiotic effect; whey protein.

Publication types

  • Review