Long COVID Definitions and Models of Care : A Scoping Review

Ann Intern Med. 2024 Jul;177(7):929-940. doi: 10.7326/M24-0677. Epub 2024 May 21.

Abstract

Background: Definitions of long COVID are evolving, and optimal models of care are uncertain.

Purpose: To perform a scoping review on definitions of long COVID and provide an overview of care models, including a proposed framework to describe and distinguish models.

Data sources: English-language articles from Ovid MEDLINE, PsycINFO, the Cochrane Library, SocINDEX, Scopus, Embase, and CINAHL published between January 2021 and November 2023; gray literature; and discussions with 18 key informants.

Study selection: Publications describing long COVID definitions or models of care, supplemented by models described by key informants.

Data extraction: Data were extracted by one reviewer and verified for accuracy by another reviewer.

Data synthesis: Of 1960 screened citations, 38 were included. Five clinical definitions of long COVID varied with regard to timing since symptom onset and the minimum duration required for diagnosis; 1 additional definition was symptom score-based. Forty-nine long COVID care models were informed by 5 key principles: a core "lead" team, multidisciplinary expertise, comprehensive access to diagnostic and therapeutic services, a patient-centered approach, and providing capacity to meet demand. Seven characteristics provided a framework for distinguishing models: home department or clinical setting, clinical lead, collocation of other specialties, primary care role, population managed, use of teleservices, and whether the model was practice- or systems-based. Using this framework, 10 representative practice-based and 3 systems-based models of care were identified.

Limitations: Published literature often lacked key model details, data were insufficient to assess model outcomes, and there was overlap between and variability within models.

Conclusion: Definitions of long COVID and care models are evolving. Research is needed to optimize models and evaluate outcomes of different models.

Primary funding source: Agency for Healthcare Research and Quality. (Protocol posted at https://effectivehealthcare.ahrq.gov/products/long-covid-models-care/protocol.).

Publication types

  • Review

MeSH terms

  • COVID-19* / diagnosis
  • COVID-19* / epidemiology
  • COVID-19* / therapy
  • Delivery of Health Care / organization & administration
  • Humans
  • Post-Acute COVID-19 Syndrome*
  • SARS-CoV-2*
  • Terminology as Topic