Reversing Metabolic Dysfunction-Associated Steatotic Liver Disease Promotes Healthy Pediatric Cardiovascular Structures: The PROC Study

Menglong Li; Wen Shu; Yuchen Zou; Huidi Xiao; Yeerlin Asihaer; Mengying Guan; Nourhan Khattab; Bipin Thapa; Suman Sapkota; Sten H Vermund; Dayong Huang; Yifei Hu

doi:10.14309/ajg.0000000000002804

Reversing Metabolic Dysfunction-Associated Steatotic Liver Disease Promotes Healthy Pediatric Cardiovascular Structures: The PROC Study

Am J Gastroenterol. 2024 Aug 1;119(8):1640-1643. doi: 10.14309/ajg.0000000000002804. Epub 2024 Apr 11.

Authors

Menglong Li¹, Wen Shu¹, Yuchen Zou¹, Huidi Xiao¹, Yeerlin Asihaer¹, Mengying Guan¹, Nourhan Khattab¹, Bipin Thapa¹, Suman Sapkota¹, Sten H Vermund², Dayong Huang³, Yifei Hu^{1

4

5}

Affiliations

¹ Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China.
² Department of Microbiology of Infectious Diseases, Yale School of Public Health, and Department of Pediatrics, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
³ Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
⁴ UNESCO Chair on Global Health and Education, Peking University, Beijing, China.
⁵ Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.

PMID: 38775939
DOI: 10.14309/ajg.0000000000002804

Abstract

Introduction: We investigated the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on cardiovascular structure development in children.

Methods: We followed 1,356 children with the mean age of 6.6 years for 4.5 years in Beijing, China. We assessed the association of MASLD with cardiovascular structure (carotid intima-media thickness and left ventricular mass) outcomes at baseline and follow-up.

Results: Over follow-up, 59 children had persistent MASLD, 109 had incident MASLD (progression), and 35 had normalization of liver health. Children with MASLD normalization showed a significantly lower mean development in carotid intima-media thickness (0.161 vs 0.188 mm) and left ventricular mass (4.5 vs 12.4 g) than children with persistent MASLD.

Discussion: The control of MASLD was associated with improved cardiovascular structure development.

MeSH terms

Carotid Intima-Media Thickness*
Child
Child, Preschool
China
Fatty Liver
Female
Follow-Up Studies
Heart Ventricles / diagnostic imaging
Heart Ventricles / pathology
Heart Ventricles / physiopathology
Humans
Male
Non-alcoholic Fatty Liver Disease / complications

Abstract

MeSH terms

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