Controlled oxygen delivery to power tissue regeneration

Elizabeth Zoneff; Yi Wang; Colin Jackson; Oliver Smith; Serena Duchi; Carmine Onofrillo; Brooke Farrugia; Simon E Moulton; Richard Williams; Clare Parish; David R Nisbet; Lilith M Caballero-Aguilar

doi:10.1038/s41467-024-48719-x

Controlled oxygen delivery to power tissue regeneration

Nat Commun. 2024 May 22;15(1):4361. doi: 10.1038/s41467-024-48719-x.

Authors

Elizabeth Zoneff^{1

2}, Yi Wang^{1

2}, Colin Jackson^{3

4}, Oliver Smith^{3

4}, Serena Duchi^{5

6}, Carmine Onofrillo^{5

6}, Brooke Farrugia², Simon E Moulton^{6

7

8}, Richard Williams⁹, Clare Parish¹⁰, David R Nisbet^{11

12

13}, Lilith M Caballero-Aguilar^{14

15

16}

Affiliations

¹ The Graeme Clark Institute, The University of Melbourne, Parkville, Melbourne, VIC, Australia.
² Department of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Parkville, Melbourne, VIC, Australia.
³ Research School of Chemistry, Australian National University, Canberra, ACT, Australia.
⁴ ARC Centre of Excellence in Synthetic Biology, Australian National University, Canberra, ACT, Australia.
⁵ Department of Surgery, Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Melbourne, VIC, Australia.
⁶ Aikenhead Centre for Medical Discovery, St. Vincent's Hospital, Melbourne, VIC, Australia.
⁷ Department of Engineering Technologies, Swinburne University of Technology, Melbourne, VIC, Australia.
⁸ Iverson Health Innovation Research Institute, Swinburne University of Technology, Melbourne, VIC, Australia.
⁹ IMPACT, School of Medicine, Deakin University, Geelong, VIC, Australia.
¹⁰ The Florey Institute, The University of Melbourne, Melbourne, VIC, Australia.
¹¹ The Graeme Clark Institute, The University of Melbourne, Parkville, Melbourne, VIC, Australia. [email protected].
¹² Department of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Parkville, Melbourne, VIC, Australia. [email protected].
¹³ Melbourne Medical School, Faculty of Medicine, Dentistry and Health Science, The University of Melbourne, Melbourne, VIC, Australia. [email protected].
¹⁴ The Graeme Clark Institute, The University of Melbourne, Parkville, Melbourne, VIC, Australia. [email protected].
¹⁵ Department of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Parkville, Melbourne, VIC, Australia. [email protected].
¹⁶ Aikenhead Centre for Medical Discovery, St. Vincent's Hospital, Melbourne, VIC, Australia. [email protected].

Abstract

Oxygen plays a crucial role in human embryogenesis, homeostasis, and tissue regeneration. Emerging engineered regenerative solutions call for novel oxygen delivery systems. To become a reality, these systems must consider physiological processes, oxygen release mechanisms and the target application. In this review, we explore the biological relevance of oxygen at both a cellular and tissue level, and the importance of its controlled delivery via engineered biomaterials and devices. Recent advances and upcoming trends in the field are also discussed with a focus on tissue-engineered constructs that could meet metabolic demands to facilitate regeneration.

Publication types

Review

MeSH terms

Animals
Biocompatible Materials / chemistry
Humans
Oxygen* / metabolism
Regeneration* / physiology
Tissue Engineering* / methods

Substances

Oxygen
Biocompatible Materials