Impact of a 20 mg/kg vancomycin loading dose on early AUC target attainment

Samuel Yang; Angela Antoniello; Steven Smoke

doi:10.1016/j.diagmicrobio.2024.116355

Impact of a 20 mg/kg vancomycin loading dose on early AUC target attainment

Diagn Microbiol Infect Dis. 2024 Aug;109(4):116355. doi: 10.1016/j.diagmicrobio.2024.116355. Epub 2024 May 18.

Authors

Samuel Yang¹, Angela Antoniello², Steven Smoke³

Affiliations

¹ Rutgers, the State University of New Jersey, Ernest Mario School of Pharmacy 160 Frelinghuysen Rd, Piscataway, NJ 07054, USA. Electronic address: [email protected].
² Cooperman Barnabas Medical Center 94 Old Short Hills Road, Livingston, NJ 07039, USA.
³ Newark Beth Israel Medical Center 202 Lyons Ave, Newark, NJ 07112, USA.

PMID: 38788550
DOI: 10.1016/j.diagmicrobio.2024.116355

Abstract

This retrospective chart review evaluated whether 20 mg/kg vancomycin loading doses increase early area under the curve (AUC) target attainment within 48 hours in comparison to non-loading dose regimens. There were no differences between groups for the primary outcome (46 % vs. 50 %; P = 0.58).

Keywords: AUC; Acute kidney injury; Loading dose; Target attainment; Vancomycin.

MeSH terms

Adult
Aged
Anti-Bacterial Agents* / administration & dosage
Anti-Bacterial Agents* / pharmacokinetics
Area Under Curve*
Female
Humans
Male
Middle Aged
Retrospective Studies
Vancomycin* / administration & dosage
Vancomycin* / pharmacokinetics

Substances

Vancomycin
Anti-Bacterial Agents