Interleukin 21 promotes IgG1+ plasma cell differentiation instead of class switching to IgE via Blimp1 expression

Eur J Immunol. 2024 Aug;54(8):e2451041. doi: 10.1002/eji.202451041. Epub 2024 May 25.

Abstract

IgE is induced by the presence of IL-4 by class switching from IgM through IgG1 to IgE. IL-21 inhibits the IgE class switch by induction of Blimp1 leading to Stat6 and AID downregulation, and plasmablast/plasma cell differentiation.

Keywords: Class switch; IL‐21; IgE; IgG1; Plasma cell.

Publication types

  • Letter

MeSH terms

  • Animals
  • Cell Differentiation* / immunology
  • Immunoglobulin Class Switching*
  • Immunoglobulin E* / immunology
  • Immunoglobulin G* / immunology
  • Interleukin-21
  • Interleukin-4 / immunology
  • Interleukin-4 / metabolism
  • Interleukins* / immunology
  • Interleukins* / metabolism
  • Mice
  • Plasma Cells* / immunology
  • Positive Regulatory Domain I-Binding Factor 1* / genetics
  • Positive Regulatory Domain I-Binding Factor 1* / metabolism

Substances

  • Positive Regulatory Domain I-Binding Factor 1
  • Immunoglobulin E
  • Interleukin-21
  • Immunoglobulin G
  • Interleukins
  • Prdm1 protein, mouse
  • Interleukin-4