Correction: Porphyrin overdrive rewires cancer cell metabolism

Swamy R Adapa; Gregory A Hunter; Narmin E Amin; Christopher Marinescu; Andrew Borsky; Elizabeth M Sagatys; Said M Sebti; Gary W Reuther; Gloria C Ferreira; Rays Hy Jiang

doi:10.26508/lsa.202402816

Correction: Porphyrin overdrive rewires cancer cell metabolism

Life Sci Alliance. 2024 May 20;7(8):e202402816. doi: 10.26508/lsa.202402816. Print 2024 Aug.

Authors

Swamy R Adapa^{1

2}, Gregory A Hunter³, Narmin E Amin⁴, Christopher Marinescu¹, Andrew Borsky³, Elizabeth M Sagatys⁵, Said M Sebti⁶, Gary W Reuther⁴, Gloria C Ferreira^{3

7

2}, Rays Hy Jiang^{8

2}

Affiliations

¹ USF Genomics Program, Center for Global Health and Infectious Diseases, College of Public Health, University of South Florida, Tampa, FL, USA.
² Global and Planetary Health, College of Public Health, University of South Florida, Tampa, FL, USA.
³ Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
⁴ Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
⁵ Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
⁶ Department of Pharmacology and Toxicology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
⁷ Department of Chemistry, College of Arts and Sciences, University of South Florida, Tampa, FL, USA.
⁸ USF Genomics Program, Center for Global Health and Infectious Diseases, College of Public Health, University of South Florida, Tampa, FL, USA [email protected].

Abstract

Cancer cells exhibit a metabolic phenotype termed “porphyrin overdrive,” characterized by dysregulated heme metabolic pathways for intermediate accumulation. This rewiring is cancer-essential and cancer-specific. Targeting this vulnerability with a “bait-and-kill” strategy shows promise in eradicating malignant cells.

Publication types

Published Erratum