The tale of capturing Norrin

Elife. 2024 May 30:13:e98933. doi: 10.7554/eLife.98933.

Abstract

Detailed binding experiments reveal new insights into the Norrin/Wnt signaling pathway that helps to control vascularization in the retina.

Keywords: Norrie disease; Norrin; Tspan12; Wnt/β-catenin pathway; molecular biophysics; none; signaling; structural biology.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Eye Proteins* / genetics
  • Eye Proteins* / metabolism
  • Humans
  • Nerve Tissue Proteins* / genetics
  • Nerve Tissue Proteins* / metabolism
  • Protein Binding
  • Retina* / metabolism
  • Wnt Signaling Pathway*

Substances

  • Eye Proteins
  • Nerve Tissue Proteins
  • NDP protein, human