Pathogenesis of chronic enteropathy associated with the SLCO2A1 gene: Hypotheses and conundrums

World J Gastroenterol. 2024 May 21;30(19):2505-2511. doi: 10.3748/wjg.v30.i19.2505.

Abstract

Chronic enteropathy associated with the SLCO2A1 gene (CEAS) is a complex gastroenterological condition characterized by multiple ulcers in the small intestine with chronic bleeding and protein loss. This review explores the potential mechanisms underlying the pathogenesis of CEAS, focusing on the role of SLCO2A1-encoded prostaglandin transporter OATP2A1 and its impact on prostaglandin E2 (PGE2) levels. Studies have suggested that elevated PGE2 levels contribute to mucosal damage, inflammation, and disruption of the intestinal barrier. The effects of PGE2 on macrophage activation and Maxi-Cl channel functionality, as well as its interaction with nonsteroidal anti-inflammatory drugs play crucial roles in the progression of CEAS. Understanding the balance between its protective and pro-inflammatory effects and the complex interactions within the gastrointestinal tract can shed light on potential therapeutic targets for CEAS and guide the development of novel, targeted therapies.

Keywords: Chronic enteropathy associated with the SLCO2A1 gene; Macrophage; Prostaglandin E2; SLCO2A1; Small intestine.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Chronic Disease
  • Dinoprostone* / metabolism
  • Gastrointestinal Hemorrhage / etiology
  • Gastrointestinal Hemorrhage / genetics
  • Humans
  • Intestinal Diseases / genetics
  • Intestinal Diseases / pathology
  • Intestinal Mucosa* / metabolism
  • Intestinal Mucosa* / pathology
  • Intestine, Small / metabolism
  • Intestine, Small / pathology
  • Organic Anion Transporters* / genetics
  • Organic Anion Transporters* / metabolism
  • Ulcer / genetics
  • Ulcer / pathology

Substances

  • SLCO2A1 protein, human
  • Organic Anion Transporters
  • Dinoprostone
  • Anti-Inflammatory Agents, Non-Steroidal