Abstract
A folic acid-targeted polyurea (PURE) dendrimer was easily radiolabelled with Technetium-99m (99mTc-PUREG4-FA2) avoiding the use of additional ligands and bioconjugation chemistry. This straightforward strategy is enabled in PURE dendrimers due to their favourable surface terminal groups configuration, showing coordination capabilities and turning these biodendrimers into attractive platforms for nanoradiotheranostics.
MeSH terms
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Dendrimers* / chemistry
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Female
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Folic Acid / chemistry
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Humans
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Ligands
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Organotechnetium Compounds / chemistry
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Ovarian Neoplasms* / diagnostic imaging
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Ovarian Neoplasms* / drug therapy
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Polymers / chemistry
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Radiopharmaceuticals / chemical synthesis
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Radiopharmaceuticals / chemistry
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Technetium* / chemistry
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Theranostic Nanomedicine
Substances
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Dendrimers
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polyurea
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Technetium
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Radiopharmaceuticals
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Organotechnetium Compounds
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Ligands
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Polymers
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Folic Acid