The Clinical Aspects of COVID and Alzheimer's Disease: A Round-Up of Where Things Stand and Are Headed

J Alzheimers Dis. 2024;99(4):1159-1171. doi: 10.3233/JAD-231368.

Abstract

The link between long COVID-19 and brain/cognitive impairments is concerning and may foster a worrisome worldwide emergence of novel cases of neurodegenerative diseases with aging. This review aims to update the knowledge, crosstalk, and possible intersections between the Post-COVID Syndrome (PCS) and Alzheimer's disease (AD). References included in this review were obtained from PubMed searches conducted between October 2023 and November 2023. PCS is a very heterogenous and poorly understood disease with recent evidence of a possible association with chronic diseases such as AD. However, more scientific data is required to establish the link between PCS and AD.

Keywords: Alzheimer’s disease; COVID-19; biomarkers; cognitive impairment; long COVID; post-COVID syndrome.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease*
  • COVID-19* / complications
  • COVID-19* / epidemiology
  • Cognitive Dysfunction / etiology
  • Humans
  • Post-Acute COVID-19 Syndrome
  • SARS-CoV-2