Risk factors of poor mid-term shoulder functional outcomes of osteosynthesis using antegrade intramedullary nailing for humeral shaft fractures: a retrospective study with a minimum 5-year follow-up

BMC Musculoskelet Disord. 2024 Jun 8;25(1):456. doi: 10.1186/s12891-024-07572-1.

Abstract

Background: Osteosynthesis using antegrade intramedullary nailing for humeral shaft fractures yields satisfactory bone union rates; however, it may adversely affect postoperative shoulder function. To date, factors affecting mid- or long-term shoulder functional outcomes following intramedullary nail fixation have not been clarified. In this study, we aimed to identify the risk factors for poor mid-term functional outcomes over 5 years postoperatively following antegrade intramedullary nail osteosynthesis for humeral shaft fractures.

Methods: We retrospectively identified 33 patients who underwent surgery using an antegrade intramedullary nail for acute traumatic humeral shaft fractures and were followed up for at least 5 years postoperatively. We divided the patients into clinical failure and no clinical failure groups using an age- and sex-adjusted Constant score of 55 at the final follow-up as the cutoff value. We compared preoperative, perioperative, and postoperative factors between the two groups.

Results: Five of the 33 patients had poor shoulder functional outcomes (adjusted Constant score < 55) at a mean follow-up of 7.5 years postoperatively. Proximal protrusion of the nail at the time of bone union (P = 0.004) and older age (P = 0.009) were significantly associated with clinical failure in the univariate analyses. Multivariate analysis showed that proximal protrusion of the nail (P = 0.031) was a risk factor for poor outcomes.

Conclusions: The findings of this study provide new information on predictive factors affecting mid-term outcomes following osteosynthesis using antegrade nails. Our results demonstrated that proximal protrusion of the nail was significantly associated with poor mid-term functional shoulder outcomes. Therefore, particularly in older adults, it is essential to place the proximal end of the intramedullary nail below the level of the articular cartilage.

Keywords: Humeral shaft fracture; Intramedullary nail; Nail protrusion; Older age; Outcome; Shoulder.

MeSH terms

  • Adult
  • Aged
  • Bone Nails*
  • Female
  • Follow-Up Studies
  • Fracture Fixation, Intramedullary* / adverse effects
  • Fracture Fixation, Intramedullary* / instrumentation
  • Fracture Fixation, Intramedullary* / methods
  • Fracture Healing
  • Humans
  • Humeral Fractures* / surgery
  • Male
  • Middle Aged
  • Range of Motion, Articular
  • Recovery of Function
  • Retrospective Studies
  • Risk Factors
  • Shoulder Joint / physiopathology
  • Shoulder Joint / surgery
  • Treatment Outcome
  • Young Adult