The 19th FASEB Science Research Conference on “Calcium and Cell Function” was organized in Malahide, Ireland, on June 25–30, 2023. Co-chaired by Mohamed Trebak (University of Pittsburgh) and Yubin Zhou (Texas A&M University), with Jen Liou and Ilya Bezprozvanny (University of Texas Southwestern) as co-vice chairs. The conference, which was attended by over 125 scientists from North America, Europe, and Asia was partially supported by the Physiological Society. Some of the authors who presented their work at the conference contributed five manuscripts to the Journal of Physiology.