Association between N-terminal pro-brain natriuretic peptide and maximal functional capacity in heart failure with preserved ejection fraction: The modifying role of obesity

Obes Res Clin Pract. 2024 May-Jun;18(3):226-231. doi: 10.1016/j.orcp.2024.05.005. Epub 2024 Jun 12.

Abstract

This study investigates the association between maximal functional capacity (peakVO2) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in 133 ambulatory patients with heart failure with preserved ejection fraction (HFpEF), focusing on patients with obesity. Across all participants, NT-proBNP inversely correlated with peakVO2. However, this association varied based on obesity status. In patients without obesity, there was an inverse relationship between NT-proBNP and peakVO2, while no significant correlation was observed in patients with obesity. These findings suggest that in stable ambulatory HFpEF, NT-proBNP did not predict peakVO2 in patients with obesity.

Keywords: HFpEF; Maximal functional capacity; NT-proBNP; Obesity; PeakVO(2).

MeSH terms

  • Aged
  • Biomarkers / blood
  • Exercise Tolerance / physiology
  • Female
  • Heart Failure* / blood
  • Heart Failure* / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain* / blood
  • Obesity* / blood
  • Obesity* / physiopathology
  • Peptide Fragments* / blood
  • Stroke Volume* / physiology

Substances

  • Natriuretic Peptide, Brain
  • pro-brain natriuretic peptide (1-76)
  • Peptide Fragments
  • Biomarkers