Bacteraemia associated with multiple septic localizations caused by Klebsiella pneumoniae sequence type ST660

Eur J Clin Microbiol Infect Dis. 2024 Aug;43(8):1655-1659. doi: 10.1007/s10096-024-04870-3. Epub 2024 Jun 13.

Abstract

We report a case of Klebsiella pneumoniae bacteraemia in an 80-year-old man in France with no history of travel to Asia, complicated by endogenous endophthalmitis, multiple cerebral microbleeds and hepatic microabscesses, associated with a Bentall endocarditis. Hypervirulence pathotype was suggested based on clinical picture, bacterial isolate genomic sequence and hypermucoidy. Interestingly, the isolate had the non-K1/K2-capsular serotype locus KL113-like, carried a KpVP-1-like virulence plasmid, and belonged to the emerging sublineage SL660 (comprising the sequence type ST660).

Keywords: Brains abscesses; Endocarditis; Hepatic microabscesses; Hypermucoidy; Hypervirulent Klebsiella pneumoniae.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Bacteremia* / microbiology
  • Cerebral Hemorrhage / microbiology
  • Endocarditis, Bacterial / diagnosis
  • Endocarditis, Bacterial / microbiology
  • Endophthalmitis / diagnosis
  • Endophthalmitis / microbiology
  • France
  • Humans
  • Klebsiella Infections* / diagnosis
  • Klebsiella Infections* / microbiology
  • Klebsiella pneumoniae* / classification
  • Klebsiella pneumoniae* / genetics
  • Klebsiella pneumoniae* / isolation & purification
  • Klebsiella pneumoniae* / pathogenicity
  • Male