Gut microbial β-Glucuronidase: A key regulator of endobiotic homeostasis

Lijun Ning; Jie Hong

doi:10.1016/j.chom.2024.05.007

Gut microbial β-Glucuronidase: A key regulator of endobiotic homeostasis

Cell Host Microbe. 2024 Jun 12;32(6):783-785. doi: 10.1016/j.chom.2024.05.007.

Authors

Lijun Ning¹, Jie Hong²

Affiliations

¹ State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai 200001, China.
² State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai 200001, China. Electronic address: [email protected].

PMID: 38870895
DOI: 10.1016/j.chom.2024.05.007

Abstract

Previous studies have explored the role of the gut microbiota in regulating endobiotic homeostasis, but the precise mechanisms remain unclear. In this issue of Cell Host & Microbe, Simpson et al. identified two predominant subtypes of gut microbial β-Glucuronidase (gmGUS) that can reactivate hormones and neurotransmitters to regulate endobiotic homeostasis.

MeSH terms

Animals
Bacteria / enzymology
Bacteria / genetics
Bacteria / metabolism
Gastrointestinal Microbiome* / physiology
Gastrointestinal Tract / microbiology
Glucuronidase* / genetics
Glucuronidase* / metabolism
Homeostasis*
Humans

Substances

Glucuronidase