Association between Lipoprotein(a) concentration and adverse cardiac events in patients with coronary artery disease: An observational cohort study

Navaneeth Amin; Tom Devasia; Shobha Ullas Kamath; Ganesh Paramasivam; Prasad Narayana Shetty; Ajit Singh; Ganesha Prakash N S

doi:10.1016/j.ihj.2024.06.001

Association between Lipoprotein(a) concentration and adverse cardiac events in patients with coronary artery disease: An observational cohort study

Indian Heart J. 2024 May-Jun;76(3):197-201. doi: 10.1016/j.ihj.2024.06.001. Epub 2024 Jun 11.

Authors

Navaneeth Amin¹, Tom Devasia², Shobha Ullas Kamath³, Ganesh Paramasivam⁴, Prasad Narayana Shetty⁵, Ajit Singh⁶, Ganesha Prakash N S⁷

Affiliations

¹ Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: [email protected].
² Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: [email protected].
³ Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: [email protected].
⁴ Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: [email protected].
⁵ Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: [email protected].
⁶ Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: [email protected].
⁷ Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India. Electronic address: [email protected].

Abstract

This prospective study investigated the association between lipoprotein (a) [Lp(a)] levels and adverse cardiac events in patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease. Among 600 patients, 79.16 % were male. Kaplan Meier analysis revealed significantly higher incidence rates of cardiac death, major adverse cardiac events, myocardial infarction, revascularization and stroke in patients with elevated Lp(a) (≥30 mg/dL). The Cox Regression model identified Lp(a) ≥30 mg/dL as a significant risk factor for adverse events (HR: 4.2920; 95%CI: 2.58-7.120; p < 0.05). Elevated Lp(a) levels were associated with an increased risk of adverse cardiac events in coronary artery disease patients undergoing PCI.

Keywords: Adverse cardiac events; Coronary artery disease; Lipoprotein(a).

Publication types

Observational Study

MeSH terms

Aged
Biomarkers* / blood
Coronary Artery Disease* / blood
Coronary Artery Disease* / complications
Coronary Artery Disease* / diagnosis
Coronary Artery Disease* / surgery
Female
Follow-Up Studies
Humans
Incidence
Lipoprotein(a)* / blood
Male
Middle Aged
Percutaneous Coronary Intervention*
Prognosis
Prospective Studies
Risk Factors
Survival Rate / trends

Substances

Lipoprotein(a)
Biomarkers