The role of circadian gene CLOCK in cancer

Nasot Rashed; Wenbin Liu; Xinran Zhou; Ann M Bode; Xiangjian Luo

doi:10.1016/j.bbamcr.2024.119782

The role of circadian gene CLOCK in cancer

Biochim Biophys Acta Mol Cell Res. 2024 Oct;1871(7):119782. doi: 10.1016/j.bbamcr.2024.119782. Epub 2024 Jun 12.

Authors

Nasot Rashed¹, Wenbin Liu², Xinran Zhou¹, Ann M Bode³, Xiangjian Luo⁴

Affiliations

¹ Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, PR China; NHC Key Laboratory of Carcinogenesis, the Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China.
² Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, PR China; Department of Pathology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, PR China.
³ The Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
⁴ Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, PR China; NHC Key Laboratory of Carcinogenesis, the Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan 410078, PR China; Key Laboratory of Biological Nanotechnology of National Health Commission, Central South University, Changsha, Hunan 410078, China. Electronic address: [email protected].

PMID: 38871225
DOI: 10.1016/j.bbamcr.2024.119782

Abstract

Circadian Locomotor Output Cycles Kaput (CLOCK) is one of the circadian clock genes and is considered to be a fundamental regulatory gene in the circadian rhythm, responsible for mediating several biological processes. Therefore, abnormal expression of CLOCK affects its role in the circadian clock and its more general function as a direct regulator of gene expression. This dysfunction can lead to severe pathological effects, including cancer. To better understand the role of CLOCK in cancer, we compiled this review to describe the biological function of CLOCK, and especially highlighted its function in cancer development, progression, tumor microenvironment, cancer cell metabolism, and drug resistance.

Keywords: CLOCK; Cancer; Circadian clock gene; Drug resistance; Metabolism; Tumor microenvironment.

Publication types

Review

MeSH terms

Animals
CLOCK Proteins* / genetics
CLOCK Proteins* / metabolism
Circadian Clocks* / genetics
Circadian Rhythm / genetics
Drug Resistance, Neoplasm / genetics
Gene Expression Regulation, Neoplastic
Humans
Neoplasms* / genetics
Neoplasms* / metabolism
Tumor Microenvironment* / genetics

Substances

CLOCK Proteins
CLOCK protein, human