Supramolecular Hydrogels for 3D Biosensors and Bioassays

Chemistry. 2024 Aug 19;30(46):e202400974. doi: 10.1002/chem.202400974. Epub 2024 Jul 30.

Abstract

Supramolecular hydrogels play a pivotal role in many fields of biomedical research, including emerging applications in designing advanced tools for point-of-care testing, clinical diagnostics, and lab-on-chip analysis. This review outlines the growing relevance of supramolecular hydrogels in biosensing and bioassay devices, highlighting recent advancements that deliver increased sensitivity, real-time monitoring, and multiplexing capabilities through the distinctive properties of these nanomaterials. Furthermore, the exploration extends to additional applications, such as using hydrogels as three-dimensional matrices for cell-based assays.

Keywords: 3D bioassays; 3D biosensing; Self-assembly; Supramolecular hydrogel.

Publication types

  • Review

MeSH terms

  • Biological Assay* / methods
  • Biosensing Techniques* / methods
  • Humans
  • Hydrogels* / chemistry
  • Nanostructures / chemistry

Substances

  • Hydrogels