Molecular Pathways and Animal Models of Arrhythmias

Tyler L Stevens; Sara Coles; Amy C Sturm; Catherine A Hoover; Maegen A Borzok; Peter J Mohler; Mona El Refaey

doi:10.1007/978-3-031-44087-8_67

Molecular Pathways and Animal Models of Arrhythmias

Adv Exp Med Biol. 2024:1441:1057-1090. doi: 10.1007/978-3-031-44087-8_67.

Authors

Tyler L Stevens^{1

2}, Sara Coles³, Amy C Sturm⁴, Catherine A Hoover^{5

6}, Maegen A Borzok⁵, Peter J Mohler^{1

2

7}, Mona El Refaey^{8

9}

Affiliations

¹ The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
² Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
³ Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
⁴ Genomic Medicine Institute, 23andMe, Sunnyvale, CA, USA.
⁵ Department of Biochemistry, Chemistry, Engineering and Physics, Commonwealth University of Pennsylvania, Mansfield, PA, USA.
⁶ Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.
⁷ Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
⁸ The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. [email protected].
⁹ Department of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA. [email protected].

PMID: 38884769
DOI: 10.1007/978-3-031-44087-8_67

Abstract

Arrhythmias account for over 300,000 annual deaths in the United States, and approximately half of all deaths are associated with heart disease. Mechanisms underlying arrhythmia risk are complex; however, work in humans and animal models over the past 25 years has identified a host of molecular pathways linked with both arrhythmia substrates and triggers. This chapter will focus on select arrhythmia pathways solved by linking human clinical and genetic data with animal models.

Keywords: ACM; ANK2; Action potential; Ankyrin-B; Arrhythmogenic Cardiomyopathy; Brugada syndrome; CPVT; Calcium; Catecholaminergic polymorphic ventricular tachycardia; Channelopathies; ERS; Early repolarization syndrome; FKBP12.6; HERG; KCNE2; KCNJ2; KCNJ8; KCNQ1; LQTS; Long QT syndrome; RYR2; Reentry arrhythmias; Repolarization; Ryanodine receptor; SCN5A; SQTS; Short QT syndrome; Ventricular arrhythmias; atrial arrhythmias.

MeSH terms

Animals
Arrhythmias, Cardiac* / genetics
Arrhythmias, Cardiac* / metabolism
Arrhythmias, Cardiac* / physiopathology
Disease Models, Animal*
Humans
Signal Transduction / genetics