Developing the Open Psychedelic Evaluation Nexus consensus measures for assessment of supervised psilocybin services: An e-Delphi study

J Psychopharmacol. 2024 Aug;38(8):761-768. doi: 10.1177/02698811241257839. Epub 2024 Jun 18.

Abstract

Background: Voter initiatives in Oregon and Colorado authorize legal frameworks for supervised psilocybin services, but no measures monitor safety or outcomes.

Aims: To develop core measures of best practices.

Methods: A three-phase e-Delphi process recruited 36 experts with 5 or more years' experience facilitating psilocybin experiences in various contexts (e.g., ceremonial settings, indigenous practices, clinical trials), or other pertinent psilocybin expertise. Phase I, an on-line survey with qualitative, open-ended text responses, generated potential measures to assess processes, outcomes, and structure reflecting high quality psilocybin services. In Phase II, experts used seven-point Likert scales to rate the importance and feasibility of the Phase I measures. Measures were priority ranked. Qualitative interviews and analysis in Phase III refined top-rated measures.

Results: Experts (n = 36; 53% female; 71% white; 56% heterosexual) reported currently providing psilocybin services (64%) for a mean of 15.2 [SD 13.1] years, experience with indigenous psychedelic practices (67%), and/or conducting clinical trials (36%). Thematic analysis of Phase I responses yielded 55 candidate process measures (e.g., preparatory hours with client, total dose of psilocybin administered, documentation of touch/sexual boundaries), outcome measures (e.g., adverse events, well-being, anxiety/depression symptoms), and structure measures (e.g., facilitator training in trauma informed care, referral capacity for medical/psychiatric issues). In Phase II and III, experts prioritized a core set of 11 process, 11 outcome, and 17 structure measures that balanced importance and feasibility.

Conclusion: Service providers and policy makers should consider standardizing core measures developed in this study to monitor the safety, quality, and outcomes of community-based psilocybin services.

Keywords: Delphi study; Psilocybin; consensus measures; psychedelic; quality of care.

MeSH terms

  • Adult
  • Colorado
  • Consensus*
  • Female
  • Hallucinogens* / administration & dosage
  • Hallucinogens* / adverse effects
  • Hallucinogens* / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Oregon
  • Psilocybin* / administration & dosage
  • Psilocybin* / pharmacology
  • Surveys and Questionnaires

Substances

  • Psilocybin
  • Hallucinogens