RNA: De-silencing to the rescue

James P Held; Maulik R Patel

doi:10.1016/j.cub.2024.05.011

RNA: De-silencing to the rescue

Curr Biol. 2024 Jun 17;34(12):R573-R575. doi: 10.1016/j.cub.2024.05.011.

Authors

James P Held¹, Maulik R Patel²

Affiliations

¹ Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
² Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Department of Evolutionary Studies, Vanderbilt University, VU Box #34-1634, Nashville, TN 37232, USA; Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Quantitative Systems Biology Center, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: [email protected].

PMID: 38889679
DOI: 10.1016/j.cub.2024.05.011

Abstract

The fate of transcribed RNA dictates cellular function. A new study finds that mutations in specific RNA processing machinery genes result in de-silencing of a transcript encoding a subunit of the mitochondrial electron transport chain and rescue of a mitochondrial respiratory complex I defect.

MeSH terms

Animals
Electron Transport Complex I* / genetics
Electron Transport Complex I* / metabolism
Gene Silencing
Mitochondria / genetics
Mitochondria / metabolism
Mutation

Substances

Electron Transport Complex I

Grants and funding

R35 GM145378/GM/NIGMS NIH HHS/United States