Recapitulating the tumor microenvironment in a dish, one cell type at a time

Benjamin N Ostendorf

doi:10.1016/j.crmeth.2024.100800

Recapitulating the tumor microenvironment in a dish, one cell type at a time

Cell Rep Methods. 2024 Jun 17;4(6):100800. doi: 10.1016/j.crmeth.2024.100800.

Author

Benjamin N Ostendorf¹

Affiliation

¹ Department of Hematology, Oncology, and Tumor Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: [email protected].

Abstract

The tumor microenvironment harbors a variety of different cell types that differentially impact tumor biology. In this issue of Cell Reports Methods, Raffo-Romero et al. standardized and optimized 3D tumor organoids to model the interactions between tumor-associated macrophages and tumor cells in vitro.

Keywords: CP: cancer biology; CP: stem cell.

MeSH terms

Animals
Humans
Neoplasms / pathology
Organoids* / pathology
Tumor Microenvironment*
Tumor-Associated Macrophages / immunology
Tumor-Associated Macrophages / metabolism
Tumor-Associated Macrophages / pathology