Biological activities of laminin

J Cell Biochem. 1985;27(4):317-25. doi: 10.1002/jcb.240270402.

Abstract

Laminin is a multifunctional protein with diverse biological activities. Like fibronectin, it can influence cell adhesion, growth, morphology, differentiation, migration, and agglutination as well as the assembly of the extracellular matrix. Laminin primarily affects cells of epithelial origin, and the response varies depending on the cell. Because most differentiated cells are difficult to maintain in culture, laminin may be an important supplement in studies on cell differentiation in vitro.

Publication types

  • Review

MeSH terms

  • Animals
  • Basement Membrane / physiology
  • Binding Sites
  • Cell Adhesion
  • Cell Differentiation
  • Cell Division
  • Cell Movement
  • Cells / cytology
  • Cells, Cultured
  • Chemical Phenomena
  • Chemistry
  • Collagen / metabolism
  • Extracellular Matrix / physiology
  • Hemagglutination
  • Heparin / metabolism
  • Heparitin Sulfate / metabolism
  • Laminin / physiology*
  • Macromolecular Substances
  • Molecular Weight
  • Neoplasm Metastasis
  • Proteoglycans / metabolism

Substances

  • Laminin
  • Macromolecular Substances
  • Proteoglycans
  • Heparin
  • Collagen
  • Heparitin Sulfate