The Burden of Overweight and Obesity-Associated Gastrointestinal Cancers in Low and Lower-Middle-Income Countries: A Global Burden of Disease 2019 Analysis

Pojsakorn Danpanichkul; Thanida Auttapracha; Banthoon Sukphutanan; Cheng Han Ng; Phuuwadith Wattanachayakul; Siwanart Kongarin; Priyata Dutta; Kwanjit Duangsonk; Jerapas Thongpiya; Mark D Muthiah; Daniel Q Huang; Rashid N Lui; Yuya Seko; Hirokazu Takahashi; Mazen Noureddin; Ju Dong Yang; Michael B Wallace; Karn Wijarnpreecha

doi:10.14309/ajg.0000000000002819

The Burden of Overweight and Obesity-Associated Gastrointestinal Cancers in Low and Lower-Middle-Income Countries: A Global Burden of Disease 2019 Analysis

Am J Gastroenterol. 2024 Jun 1;119(6):1177-1180. doi: 10.14309/ajg.0000000000002819. Epub 2024 Apr 22.

Authors

Pojsakorn Danpanichkul¹, Thanida Auttapracha², Banthoon Sukphutanan², Cheng Han Ng^{3

4}, Phuuwadith Wattanachayakul⁵, Siwanart Kongarin², Priyata Dutta⁶, Kwanjit Duangsonk⁷, Jerapas Thongpiya⁸, Mark D Muthiah^{3

9}, Daniel Q Huang^{3

10}, Rashid N Lui¹¹, Yuya Seko¹², Hirokazu Takahashi¹³, Mazen Noureddin¹⁴, Ju Dong Yang¹⁵, Michael B Wallace^{16

17}, Karn Wijarnpreecha^{18

19

20}

Affiliations

¹ Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
² Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
³ Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore.
⁴ Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.
⁵ Department of Medicine, Albert Einstein Healthcare Network, Philadelphia, Pennsylvania, USA.
⁶ Department of Internal Medicine, Trinity Health, Ann Arbor, Michigan, USA.
⁷ Department of Microbiology, Faculty of Medicine, Chiang Mai University, Thailand.
⁸ Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
⁹ National University Centre for Organ Transplantation, National University Health System, Singapore, Singapore.
¹⁰ MASLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, California, USA.
¹¹ Department of Clinical Oncology, and Division of Gastroenterology and Hepatology, Department of Medicine and Therapeutics, Institute of Digestive Diseases, The Chinese University of Hong Kong, Hong Kong SAR, China.
¹² Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyou-ku, Kyoto, Japan.
¹³ Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga, Japan.
¹⁴ Houston Research Institute and Houston Methodist Hospital, Houston, Texas, USA.
¹⁵ Karsh Division of Gastroenterology and Hepatology, Comprehensive Transplant Center, and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
¹⁶ Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA.
¹⁷ Department of Gastroenterology, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates.
¹⁸ Division of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, Arizona, USA.
¹⁹ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Banner University Medical Center, Phoenix, Arizona, USA.
²⁰ Department of Medicine, BIO5 Institute, University of Arizona College of Medicine, Phoenix, Arizona, USA.

PMID: 38900306
DOI: 10.14309/ajg.0000000000002819

Abstract

Introduction: Obesity is associated with cancer, including gastrointestinal (GI). Data from low (LICs) and lower-middle-income countries (MICs) are limited.

Methods: We utilized data from the Global Burden of Disease Study 2019 to determine the mortality from GI cancer risk of high body mass index (BMI) in these countries.

Results: Mortality rates of GI cancers from high BMI increased in LICs and lower MICs, while burdens decreased or remained stable in high and middle-income countries.

Discussion: The GI cancer-related burden from high BMI increased in LICs and lower MICs, necessitating a concerted effort to tackle the obesity pandemic.

MeSH terms

Adult
Aged
Body Mass Index*
Developing Countries* / statistics & numerical data
Female
Gastrointestinal Neoplasms* / epidemiology
Global Burden of Disease*
Global Health
Humans
Male
Middle Aged
Obesity* / complications
Obesity* / epidemiology
Overweight* / complications
Overweight* / epidemiology