Modulation of diabetic wound healing using carbon monoxide gas-entrapping materials

Emily Witt; Alexander J Leach; Jianling Bi; Samual Hatfield; Alicia T Cotoia; Megan K McGovern; Arielle B Cafi; Ashley C Rhodes; Austin N Cook; Slyn Uaroon; Bishal Parajuli; Jinhee Kim; Vivian Feig; Alexandra Scheiflinger; Ikenna Nwosu; Miguel Jimenez; Mitchell C Coleman; Marisa R Buchakjian; Dustin E Bosch; Michael S Tift; Giovanni Traverso; Leo E Otterbein; James D Byrne

doi:10.1016/j.device.2024.100320

Modulation of diabetic wound healing using carbon monoxide gas-entrapping materials

Device. 2024 May 17;2(5):100320. doi: 10.1016/j.device.2024.100320. Epub 2024 Mar 12.

Authors

Emily Witt^{1

2

3}, Alexander J Leach^{3

4}, Jianling Bi^{1

2

3}, Samual Hatfield^{3

4}, Alicia T Cotoia⁵, Megan K McGovern^{1

2

3}, Arielle B Cafi^{1

2

3}, Ashley C Rhodes^{1

2

3}, Austin N Cook^{1

2

3}, Slyn Uaroon^{3

6}, Bishal Parajuli⁷, Jinhee Kim^{8

9}, Vivian Feig^{9

10}, Alexandra Scheiflinger¹¹, Ikenna Nwosu^{3

4}, Miguel Jimenez^{8

9

12}, Mitchell C Coleman¹³, Marisa R Buchakjian^{3

6}, Dustin E Bosch^{3

7}, Michael S Tift⁵, Giovanni Traverso^{9

10

12}, Leo E Otterbein¹¹, James D Byrne^{1

2

3

13}

Affiliations

¹ Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.
² Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.
³ Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.
⁴ Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
⁵ Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC, 28403, USA.
⁶ Department of Otolaryngology, University of Iowa, Iowa City, IA, 52242, USA.
⁷ Department of Pathology, University of Iowa, Iowa City, IA, 52242, USA.
⁸ Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, ON M5S 1A8, Canada.
⁹ Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
¹⁰ David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
¹¹ Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
¹² Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
¹³ Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA, 52242, USA.

PMID: 38911126
PMCID: PMC11192243 (available on 2025-05-17)
DOI: 10.1016/j.device.2024.100320

Abstract

Diabetic wound healing is uniquely challenging to manage due to chronic inflammation and heightened microbial growth from elevated interstitial glucose. Carbon monoxide (CO), widely acknowledged as a toxic gas, is also known to provide unique therapeutic immune modulating effects. To facilitate delivery of CO, we have designed hyaluronic acid-based CO-gas-entrapping materials (CO-GEMs) for topical and prolonged gas delivery to the wound bed. We demonstrate that CO-GEMs promote the healing response in murine diabetic wound models (full-thickness wounds and pressure ulcers) compared to N₂-GEMs and untreated controls.

Abstract

Grants and funding