First report of Nocardia wallacei infection in an immunocompetent patient in Zhejiang province

Wei Pan; Bingqian Zhuo; Sumei Wang; Jieping Long; Wei Xu; Mengyuan Chen; Xin Hong; Yumei Ge

doi:10.1515/biol-2022-0891

First report of Nocardia wallacei infection in an immunocompetent patient in Zhejiang province

Open Life Sci. 2024 Jun 18;19(1):20220891. doi: 10.1515/biol-2022-0891. eCollection 2024.

Authors

Wei Pan¹, Bingqian Zhuo^{2

3}, Sumei Wang³, Jieping Long³, Wei Xu⁴, Mengyuan Chen⁵, Xin Hong⁶, Yumei Ge^{3

4

6}

Affiliations

¹ Department of Clinical Laboratory, Haiyan People's Hospital, Haiyan, Zhejiang, 314300, China.
² School of Public Health, Hangzhou Medical College, Hangzhou, 310053, China.
³ Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China.
⁴ School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.
⁵ The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.
⁶ Department of Green Pharmaceutical Collaborative Innovation Center, School of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, China.

Abstract

Nocardiosis is an infectious disease caused by Nocardia spp., mainly affecting immunocompromised hosts. Nocardia infection is not common; especially Nocardia wallacei infection is even rarer. The patient, female, 61 years old, farmer, has been working in the field for a long time and has normal immune function. Her main clinical manifestation was persistent back pain. Chest-enhanced computed tomography showed pulmonary inflammation. Rare pathogen Nocardia wallacei was detected in alveolar lavage fluid using matrix-assisted laser destructive ionization time-of-flight mass spectrometry. She received treatment with linezolid and was discharged after her condition improved.

Keywords: MALDI-TOF MS; Nocardia wallacei; immunocompetent; linezolid; nocardiosis.

Publication types

Case Reports