Keratin-Positive Giant Cell Tumor of Bone and Soft Tissue With HMGA2::NCOR2 Fusion in Children Under 10 With Response to Imatinib Therapy: A Case Series

JCO Precis Oncol. 2024 Jun:8:e2300659. doi: 10.1200/PO.23.00659.

Abstract

HMGA2::NCOR2 keratin-positive giant cell tumors in children with response to imatinib in an infant.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Bone Neoplasms / drug therapy
  • Female
  • Giant Cell Tumor of Bone / drug therapy
  • Giant Cell Tumor of Bone / genetics
  • HMGA2 Protein* / genetics
  • Humans
  • Imatinib Mesylate* / therapeutic use
  • Infant
  • Keratins
  • Male
  • Soft Tissue Neoplasms* / drug therapy
  • Soft Tissue Neoplasms* / genetics
  • Soft Tissue Neoplasms* / pathology

Substances

  • Antineoplastic Agents
  • HMGA2 Protein
  • HMGA2 protein, human
  • Imatinib Mesylate
  • Keratins