IL-3: key orchestrator of inflammation

Front Immunol. 2024 Jun 13:15:1411047. doi: 10.3389/fimmu.2024.1411047. eCollection 2024.

Abstract

Interleukin (IL)-3 has long been known for its hematopoietic properties. However, recent evidence has expanded our understanding of IL-3 function by identifying IL-3 as a critical orchestrator of inflammation in a wide array of diseases. Depending on the type of disease, the course of inflammation, the cell or the tissue involved, IL-3 promotes either pathologic inflammation or its resolution. Here, we describe the cell-specific functions of IL-3 and summarize its role in diseases. We discuss the current treatments targeting IL-3 or its receptor, and highlight the potential and the limitations of targeting IL-3 in clinics.

Keywords: CD123; cancer; infection; inflammation; interleukin-3.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation* / immunology
  • Inflammation* / metabolism
  • Interleukin-3* / metabolism
  • Receptors, Interleukin-3 / immunology
  • Receptors, Interleukin-3 / metabolism
  • Signal Transduction

Substances

  • Interleukin-3
  • Receptors, Interleukin-3

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the grants of the German Research Foundation BE6981/1–1 and BE6981/4–1 (AB).